Comparing and Contrasting the Two Films Back to the Future and Temple Assignment

Comparing and Contrasting the Two Films Back to the Future and Temple of Doom - Assignment Example The essay seeks to highlight how similar and how different are the ideas of race; class and gender appear in the two films.The article analyzes both setting and characterization in the two films to understand the philosophies. The race is a rare fact that many children fail to understand while watching the two movies. In both the films, the ideology of racism is hidden that one cannot identify by just watching but must keep a close understanding of the setting and characters. In the film back to the future, racism is depicted by both how characters are viewed in society and how they are treated. When Marty gets back to his house only to find black families living in it the film, shows a neighborhood with burnt out cars and houses. The burnt ugly area depicts a filthy life the blacks live. Another aspect of racism in the film is the characters that are given to the blacks. The blacks are band players or individual living in projects. The scenario gives a racist impression that blacks are good for nothing. Pierre Caliste in his quest for the mayor position, he never believed himself and had to consult a white man Marty to proceed. Similarly, in the film temple of doom, the Shanghai gangsters laugh at Indy after poisoning her wine, and they kept the rescue antidote. The plane flying from China only to crash in Indian soil is also a racial impression of the difference in advancement. Slavery to the weaker race is evident with the kids kidnaped in the village of Thuggees. The two films contrast in gender representation. The film temple of doom is arguably unkind to the women characters prompting the review of the gender ideology. The women characters are represented as shallow beginners by the character Willie. All through the movie, she appears to have little knowledge of her strengths and capabilities. The apparent show of diminished profile for women character is at the ending episodes. After Willie showing little development, Dr. Jones humbles her to a weak damsel in agony  when she is seductively drawn in for a kiss. However, there is a good gesture for female characters in the film back to the future.  

Medical Law and Ethics Essay Example | Topics and Well Written Essays - 500 words

Medical Law and Ethics - Essay Example As a matter of fact, caregivers’ licenses may be revoked if the board concedes that their failure to advocate fiercely for their patient's wellbeing played a critical role in the patients’ deterioration or even death. This paper will examine caregivers’ acceptable actions in the event that they dispute wrong physicians’ written orders. Â  Caregivers have the right to refuse certain physicians’ written orders, particularly in the event that they believe that the written orders are contraindicated, do not conform to accepted hospital protocols and procedures, or can ultimately endanger the patients’ overall wellbeing. However, caregivers should give explanations for their decisions to violate physicians’ written orders, then document their reasons, making sure to adhere to all hospital rules and protocols. Most hospitals have in place policies that clearly explain the procedures to follow when dealing with and speaking to wrong physician orders, which can include, among others, wrong prescriptions and treatment protocols (Harris, 2008). However, it is critical that caregivers voice their oppositions to the written orders to the relevant physician to ensure appropriate changes are made in order to guarantee that the patient receives the optimal quality of healthcare. However, in some instances, p hysicians may be hard-headed and refuse to accept caregivers’ corrections. In such cases, it is vital that caregivers follow the right procedures established by the hospital administration to seek changes in the written orders to deter the incidence of harm to patients. Nonetheless, provided that the caregiver is sure that the physician’s written orders are wrong, he or she is legally permissible to violate the orders and, in turn, institute appropriate measures and treatment protocols, which are guaranteed to help the patient attain optimal health. Â  

Environmental Issues In Real Estate Essay Example for Free

Environmental Issues In Real Estate Essay Real estate transactions involve the purchase of land properties and generally, environmental issues are frequently considered before a sale is completed. Environmental issues are usually taken into account, be it a residential real estate property, or a huge industrial piece of land. Should environmental risks be associated in a particular real estate property, these are frequently manageable, but the more critical issue regarding environmental issues is the efficient identification and reaction to these environmental issues (Goeters, 1996). Most problems arise after a real estate property sale because the environmental issues were not detected as early as possible. The most common environmental issue that is associated with real estate is land contamination. Such environmental issues generally come from the activities of the present or past owners, or better categorized as on-site contamination. Another source of land contamination could be off-site, which involves the physical location of the real property to outside sources of contamination. It is important that the source of the contamination of the land be identified so that the amount of risk may be determined. In addition, knowledge of the contamination source allows sanctions for property responsibility. Issues are considered severe when the water reservoir and its connecting waterways for drinking water are already affected or positioned near the real estate property. Another environmental issue that is considered as a major concern in real estate is mold contamination. The spread of pathogenic fungi and its spores frequently originate from buildings that are erected using low-quality standards and currently have poor ventilation. Such fungi often generate spores that are usually air-borne and may be transmitted through wind and any air circulating system. These spores may also stick to the walls of an existing building that is situated on the real estate property. Not only do fungal spores cause future deterioration to a building, these spores may even cause upper respiratory tract infections, allergies and immune reactions in the individuals that frequent the area involved. Several lawsuits have accumulated in connection to personal injuries or diseases causes by exposure to these pathogenic fungi. In addition, the insurance industry has lately been involved in cases that involve exposure to building-related real estate properties. Furthermore, fungal contamination involves all types of real estate properties, including residential, commercial and industrial buildings, and the effect of such contamination is doubly felt because the building’s structure itself will continuously deteriorate unless treated, and the residents of the home or the employees of a commercial or industrial company make succumb to fungi-caused illnesses. It has been strongly suggested that owners of real estate properties be cautious of the insurance coverage they procure for their employees should such untoward incident occurs in their company or industry. Asbestos is also an environmental issue that should be carefully considered in real estate. Asbestos is generally a component of pipes and boiler rooms, as well as in flooring materials and in roofs. Asbestos exposure cases are often higher in number in commercial and industrial companies, yet these cases may also occur in residential real estate properties. The amount of money require to solve any presence of asbestos in a building is usually huge, hence it should always be kept in mind that any possible cause for asbestos exposure be pointed out as early as possible, before any exposure is determined to be chronic, which is turn results in more severe health problems among individuals associated with the real estate property. Individuals practicing in the real estate business should be sincere enough to advise the client about any information that may be associated with asbestos presence or exposure within a real estate property he is showing and selling. Another element that has been identified as an environmental issue in real estate is radon. Radon gas shows no color or odor, and is very diffusible through water and air. This gas has been frequently reported in residential real estate properties, hence it is important that the water and air of a real estate property be tested for radon gas before any further step is taken towards the purchase or sale of a real estate property. Unfortunately, the safe or tolerable level of radon gas has not been established to date, hence any tests for the presence of radon gas in the water or in the air is just to satisfy the need to know where radon gas is indeed present in a real estate property. Real estate properties such as buildings and houses are often presented to potential buyers as painted structures that are ready for occupancy. Hence, the environmental concern for lead in the paint used to coat the walls of the rooms of the real estate property is also an issue. Individuals most affected by the presence of lead in the paint used to coat the walls are the young children who often play on the floor of the rooms of a residential establishment. Young toddlers often crawl around the house and unfortunately, ingest any little thing they find interesting in front of them. These little things may be lead paint chips that fall off from the wall and ceiling and land on the carpet, floor, or even the soil in the backyard. Other families enjoy gardening and planting their own vegetables, hence the presence of lead in the soil may pose a bioaccumulation of lead in the people living in this contaminated real estate property. It is therefore important that pre-erected real estate structures be evaluated for the presence of lead before any further step in done towards the purchase of the real estate property. Should lead be detected in a real estate property, an abatement procedure may be performed before any family or individuals move into the real estate property. Currently, there are several assays that may be employed in the identification and management of environmental issues associated with real estate properties (Spada, 1997). Hence, it is imperative that these environmental factors be tested before any purchase is done on a real estate property, because it these factors go undetected, the consequences on the personal health of the individuals that will live or frequently spend time within the real estate property will be affected. Such undisclosed environmental issues often end up in lawsuits, as well as tarnished reputations in the real estate business. Hence, for those in the real estate business, it is of prime importance that reliable and specific information be obtained about the real estate property they are advertising and selling. Such caution regarding the collection of information will serve as a good method is preserving the real estate business of a company. Certain real estate companies have established their own customized procedure in reviewing properties before they release these properties to the public and announce that this property is for sale. These customized procedures should be foolproof, robust and efficient in identifying environmental issues in a real estate property. Should this be kept in mind, there would probably be lesser cases of lawsuits and health illnesses in the future.

Structure and Uses of Ibuprofen

Structure and Uses of Ibuprofen Abstract The Controlled-release dosage forms are formulated to release the drugs active ingredient gradually and predictably over an extended period of time that is something like 12 to 24 hour period. â€Å"These formulations potentially provide for greater effectiveness in the treatment of chronic conditions through more consistent delivery of the medication; reduced side effects; greater convenience; and higher levels of patient compliance due to a simplified dosage schedule, compared with those of immediate-release drugs†. Ibuprofen is a colourless, crystalline solid which is having a low soluble limits in water but it is having a better solublity in most organic solvents. â€Å"The main aim of this work is control the release of drug by encapsulating it in to coating materials like fattyacids (palmiticacid and pluronic F-127). Encapsulating of ibuprofen by using freeze drying technique in this technique Ibuprofen is encapsulated in to the fattyacid and pluronic (F127), these coating materials have the property of controlling the release of drug when the coated drug is entered in to the body the coating materials which surrounded to the drug is control the release of drug†. The release of encapsulated ibuprofen is determined by Flow through dissolution and UV- visible spectroscopy. INTRODUCTION 1. IBUPROFEN Ibuprofen is a colourless, crystalline solid which is having a very very low solubility limits I case of water but it is having comparabelly better soluble limits in case of organic solvents. The synthesis of ibuprofen was originally reported in 1964 from Ï -isobutyl- lacetophen but the drug was not marketed in the United States until 1974 despite the fact that it had been available for several years in Europe. â€Å"It was the indomethacin and was immediately accepted in therapy. Its success was a factor in the introduction of many new agents in the 1970s. Ibuprofen was the first aryl propionic acid derivative to be marketed in the United States†. This chemical class currently comprises of the largest group of NSAIDs under investigation with as many as 25 derivatives in various stages of development. â€Å"It recently became the first prescription NSAIA to become available as an over the counter analgesic in almost 30 years and is avialble under a number of trade names, It is also sometimes known as: Advil, Anadin Ibuprofen, Arthrofen, Brufen, Retard, Cuprofen, Fenbid; Galprofen, Hedex Ibuprofen, Ibufem; Librofem; Mandafen; Manorfen; Migrafen; Motrin; Nurofen; Obifen; Relcofen perhaps being among the more widely used. The continuing popularity of ibuprofen is evidenced by the appearance 200 prescription drugs in the United States†. IUPAC name : 2-[4-(2-methylpropyl) phenyl] propanoacid, Formula : C13H18O2, Molecular mass : 206.28, Melting point : 76  °C (1. 69  °F) Bioavailability : 49-73, Protein binding : 99%, Metabolism : Hepatic, Half life : 1.8-2 hours, Excretion : Renal. 1.1 Structure of Ibuprofen Structure of IBUPROFEN Ibuprofen is a white powder belonging to the propionic acid derivatives, with a melting point of 74 77 ° C. It is only slightly soluble in water but readily soluble in organic solvents such as ethanol. It is a chiral compound; racemic Ibuprofen is usually used, although only one form is active medicinally. â€Å"Ibuprofen is made up of covalently-bonded carbon, hydrogen, and oxygen atoms. 2 CH3 molecules are single-bonded to a CH molecule The CH molecule is bonded to a carbon atom that forms a 6-sided ring of carbon atoms†. Another CH molecule is single-bonded to a carbon atom on the other side of the ring. Inside the ring there are 3 double bonds between carbon atoms. Then another CH3 molecule and a COOH molecule are both single bonded to the CH molecule on the right. Because it is nonsteroidal, it is widely used as it does not upset the hormonal balance in the body. Its anti-inflammatory, analgesic (pain relieving) and antipyretic (fever reducing) actions are co moderate pain such as headache, toothache, and migraine as well as symptoms of fever. 1.2 Stereochemistry Ibuprofen contains a chiral carbon in the ∞ position of the propionate moiety. As such, there are two possible enantiomers of ibuprofen, with the potential for different biological effects and metabolism for each enantiomer. Indeed it was found that (S)(+)- ibuprofen (dexibuprofen) was the active form both in vitro and in vivo, because of this reason the ibuprofen is marketed as a single enantiomer as occurs with naproxen and other NSAIDs. And the in vivo experiments revealed the existence of an Isomerase (2-arylpropionylco-A epimerase) which converted (R) -ibuprofen to the active (S)-enantiomer .Most of the ibuprofen formulations are marketed as racemic mixtures. Racemic ibuprofen is an important NSAID used in the treatment of pain and inflammation in a variety of musculoskeletal rheumatic disorders. 1.3 Synthesis â€Å"There have been many commercial and laboratory publications for the synthesis of Ibuprofen. Two of the most popular ways to obtain Ibuprofen are the Boot process and the Hoechst process. The Boot process is an older commercial process developed by the Boot Pure Drug Company, and the Hoechst process is a newer process developed by the Hoechst Company. Most of these routes to Ibuprofen begin with isobutyl benzene and use Friedel-Crafts acylation. The Boot process requires six steps, while the Hoechst process, with the assistance of catalysts, is completed in only three steps†. Cheminor Drugs have developed a process for an improved version of ibuprofen based on chiral synthesis. The move is significant given that pure S-Ibuprofen (the active form of ibuprofen) could near halve the regular ibuprofen dosage, besides improving the side-effect profile. However the human body can convert the inactive (R) form into the (S) form, so eventually 100% of the ibuprofen taken becomes active. The process discovered by Cheminor is therefore unlikely to have commercial significance. [6] 1.4 Mechanism of action: â€Å"Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variants of cyclooxygenase (COX-1 and COX-2). Ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity is achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa†. The role of the individual COX isoforms in the analgesic, anti-inflammatory, and gastric damage effects of NSAIDs is uncertain and different compounds cause different degrees of analgesia and gastric damage. 1.5 Absorption and metabolism: Ibuprofen is quite rapidly absorbed when it is admistered orally we can witness the peak plasma levels are obtained withan 2hours time.† As with most of these acidic NSAIDs , ibuprofen(pka=4.43) is extensively bound to the plasma proteins(99%) and will interact with other acidic drugs which are protein bound. Metabolism occur rapidly and the drug is nearly completely excreted in the urine as UN changed drug and oxidative metabolites with in 24 hrs following administration†. Metabolism involves primarily ω-1and ω-2 oxidation of the Ï -iso butyl side chain, followed by alcohol oxidation of the primary alcohol resulting from the ω-oxidation to the corresponding carboxylic acid. All metabolites are essentially in active. When Ibuprofen id administered as the individual enantiomers, the major metabolites isolated are the (+)-isomers regardless of the configuration of the administered enantiomer.intrestingley, the (R)(-)-enantiomer is inverted to the (S)-(+)-enant iomer in vivo, accounting for the observation that the two enantiomers are bioequivalent In vivo. 1.6 Ibuprofen uses: Ibuprofen is used to relief the symptoms of a wide range of illnesses such as headaches, backache, period pain, dental pain, neuralgia, rheumatic pain, muscular pain, migraine, cold and flu symptoms and arthritis. Recently evidence has emerged suggesting that ibuprofen is effective in the treatment of Alzheimers disease. 1.7 Ibuprofen side effects Ibuprofen is regarded as the first choice drug in its class due to the low number of side effects and complications associated with it. The most frequent type of adverse reaction occurring with ibuprofen is gastrointestinal. In clinical trials, the percentage of patients reporting one or more gastrointestinal complaints ranged from 4% to 16%. Common Side Effects: stomach upset or irritation Infrequent Side Effects: nausea and/or vomiting, constipation, diarrhoea Rare Side Effects: skin irritations, drowsiness, gastrointestinal bleeding Ibuprofen has the lowest incidence of gastrointestinal adverse effects, reactions of all the non selective NSAIDS. However this only holds true in case of lower doses of ibuprofen, so over the counter preparation of ibuprofen are generally labelled to advise a maximum daily dose of 1,200 mg. 1.8 Risks involved 1.8.1 Cardiovascular Risk: Along with several other NSAIDs, ibuprofen has been implicated in elevating the risk of myocardial infarction, particularly among those chronically using high doses. 1.8.2 Risks in Pregnancy: Ibuprofen consumption should be avoided in late pregnancy due to risk of premature closure of the ducts arteries in the fetal heart. 1.8.3 Risks in Inflammatory Bowel Disease â€Å"Ibuprofen should not be used regularly in individuals with Inflammatory Bowel Diseas (IBD-Crohns Disease and Ulcerative Colitis)due to its ability to cause gastric bleeding and form ulceration in the gastric lining. Drugs such as Advil should be avoided in persons afflicted with IBD. Pain relievers such as Tylenol (containing acetaminophen) or drugs containing Codeine (which slows down bowel activity) are safer methods than Ibuprofen for pain relief in IBD†. Ibuprofen is also known to cause worsening of IBD during times of a flare-up, thus should be avoided completely. 1.8.4Drug-Drug Interactions Ibuprofen is associated with several suspected or other probable interactions that can affect the action of other drugs .Ibuprofen leads to the increased levels of lithium leading to the reduction of lithium excretion from the kidneys, and this may lead to lithium toxicity. Ibuprofen may lead to the lowering of blood pressure because prostaglandins play an important role in reducing the blood pressure. Ibuprofen is used in combination with amino glycosides for e.g.: The blood levels of gentamycin may increase presumably because the elimination of amino glycosides from the body is reduced and may lead to amino glycoside side effect. 1.9. Absorption and Metabolism Ibuprofen is rapidly absorbed on oral administration with peak plasma levels being generally attained with in 2hrs. As with most of these acidic NSAIDs , ibuprofen(pka=4.43) is extensively bound to the plasma proteins(99%) and will interact with other acidic drugs which are protein bound. Metabolism involves primarily ω-1and ω-2 oxidation of the Ï -iso butyl side chain, followed by alcohol oxidation of the primary alcohol resulting from the ω-oxidation to the corresponding carboxylic acid. All the metabolites are essentially inactive. The (R)(-)-enantiomer is inverted to the (S)-(+)-enantiomer in vivo, accounting for the observation that the two enantiomers are bioequivalent In vivo. 1.9 Mechanism of Action Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. Prostaglandins are produced in response to injury or certain diseases 2 variants of cyclooxygenase (COX-1 and COX-2). Ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity is achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. The role of the individual COX Isoforms in the Analgesic, Antiinflammatory, and the Gastric damage and affects of NSAIDs is uncertain and different degrees of Analgesia and Gastric damage occur. 1.10 Controlled Release Mechanisms Controlled release implies regulation of the delivery of a a drug by a device the control is aimed at delivering the drug at a specific rate for a definite period of time independent of the local environments. Controlled release may also incorporate methods of promote localization of drug at an active site. Site specific and targeted delivery systems are the descriptive term used to denote this type of control. The periods of delivery are much longer than in case of sustained release and may vary from days to years. Controlled release mechanism is designed to release the drug in vivo according to predictable rates that can be verified by in-vitro measurements. Controlled release technology implies a quantities understanding of the physic chemical mechanism of drug availability to the extent that the dosage form release rate can be specified. Potential development s and new approaches to oral controlled release drug delivery systems, intragastric floating tablets, Trans mucosal tablets and micro porous membrane coated tablets . An example of application to the controlled release technology to dosage form design consists of a polymer matrix in which a drug containing solution is dispersed in the form of micro cells. The barrier permeability and the drug solubility in the dispersed solution are variables that can be adjusted to provide predictable drug release rates. All pharmaceutical dosage forms should be controlled release formulations -with rate specified and bioavailability assured by the drug delivery design. There are three types of controlled release mechanisms: Ø Diffusion Ø Swelling Ø Degradation 2 .Palmitic acid Palmitic acid,CH3(CH2)14COOH or hexadecanoic acid in IUPAC nomenclature, is one of the most common saturated fatty acids found in animals and plants. As its name indicates, it is a major component of the oil from palm trees (palm oil and palm kernel oil). Palmitate is a term for the salts or esters of palmitic acid. The palmitate anion is the observed form of palmitic acid at physiological pH. CAS number 57-10-3 Molecular formula C16H32O2 Molar mass 256.42 g/mol Appearance White crystals Density 0.853 g/cm3 at 62  °C Melting point 63-64  °C Boiling point 351-352  °C[2] 215  °C at 15 mmHg Solubility in water Insoluble 2.1 Biochemistry â€Å"Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl- CoA carboxyl(ACC) which is responsible for converting acetyl-CoA to malonyl-CoA which is used to add to the growing acyl chain, thus preventing further palmitate generation. Reduction of palmitic acid yields cetyl alcohol†. 2.2 Uses Derivatives of palmitic acid were used in combination with naphtha during World War II to produce napalm (aluminum naphthenate and aluminum palmitate). [6] â€Å"The World Health Organization claims there is convincing evidence that dietary intake of palmitic acid increases risk of developing cardiovascular diseases. However, possibly less-disinterested studies have shown no ill effect, or even a favorable effect, of dietary consumption of palmitic acid on blood lipids and cardiovascular disease, so that the WHO finding may be deemed controversial.[8] However, another study showed that palmitic acid has no hypercholesterolaemic effect if intake of linoleic acid is greater than 4.5% of energy. On the other hand, it was shown that, if the diet contains trans fatty acids, the health effects are negative, causing an LDL cholesterol increase and HDL cholesterol decrease†. â€Å"Recently, a long-acting anti-psychotic medication, paliperidone palmitate (marketed as INVEGA Sustenna), used in the treatment of schizophrenia, has been synthesized using the oily palmitate ester as a long-acting release carrier medium when injected intramuscularly. The underlying method of drug delivery is similar to that used with decanoic acid to deliver long-acting depot medication, in particular, neuroleptics such as haloperidol decanoate†. 3 .Pluronic F-127 Pluronic F127 is a difunctional block copolymer surfactant terminating in primary hydroxyl groups. A non-ionic surfactant that is 100% active and relatively nontoxic. 3.1 Specifications Cloud point (10% aqueous)†¦.. >100 °C Color, APHA †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 120 max. Water, weight %†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. Cast Solid-0.4 max. Prill/Micropastille-0.75 max. pH (2.5% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 6.0 7.0 3.2 Typical physical properties Form†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Cast solid /Prill /Micropastille Average molecular weight†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦ 12600 Specific gravity, 77 °/25 °C†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 1.05 Viscosity, cps at 77 °C †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 3100 Melt Point†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. 56 °C Cloud point (1% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦ >100 °C Foam height (Ross Miles, 0.1% aqueous at 50 °C)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 40 mm Surface tension (0.1% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 41 dynes/cm at25 °C HLB†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 18 − 23 Solubility in water at 25 °C†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. >10% Wetting, Draves Sink Time (3-gm hook, 0.1% aqueous at 25 °C)†¦.. >360 seconds â€Å"Pluronicf-127 is polymer with an additional property in aqueous solution which will covert from its liquid state to that of a non fluid hydrogel, which is a main characteristic of the protein drug delivery system†.Pluronic-f127 is also considered as an Thermo Reversible Gelatine of the co-polymer f127 whose generic name is 407 in water makes it an unique candidate for Microencapsulaton application â€Å"Pluronic-f127 is a surfactant molecule with highly beneficial characteristics that makes it a strong candidate for protein drug delivery system. Its interaction with the polypeptides is most likely of minimisation of potential energy by mutual exclusion of hydrophobic residues from the aqueous medium as was predicted by computer probing and verified by fluorescent probing†. 4. Microencapsulation This is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. These micro-capsules have a number of benefits such as converting liquids to solids, separating reactive compounds, providing environmental protection, improved material handling properties. Active materials are then encapsulated in micron-sized capsules of barrier polymers (gelatin, plastic, wax, ). â€Å"The reasons for micro encapsulation are countless. In some cases, the core must be isolated from its surroundings, as in isolating vitamins from the deteriorating effects of oxygen, retarding evaporation of a volatile core, improving the handling properties of a sticky material, or isolating a reactive core from chemical attack. In other cases, the objective is not to isolate the core completely but to control the rate at which it leaves the microcapsule, as in the controlled release of drugs or pesticides†. The problem may be as simple as masking the taste or odour of the core, or as complex as increasing the selectivity of an adsorption or extraction. 4.1 Micro encapsulation techniques: *Physical methods of encapsulation > Rotary disk atomization > Fluid bed coating > Stationary nozzle co extrusion > Centrifugal head co extrusion > Submerged nozzle co extrusion > Spray drying > Pan coating * Chemical methods of encapsulation > Phase separation > Solvent evaporation > Solvent extraction > Interfacial polymerization > Simple and complex coacervation > In-situ polymerization > Liposome technology * Shell materials used for en capsulation > Proteins > Polysaccharides > Starches > waxes > Fats > Natural and synthetic polymers > Resins 4.2 Chemicals used in this experiment: Drug: IBUPROFEN Coating polymer: pvp and pluronic (f77) Phosphate buffer (7.4) Composition of phosphate buffer Ø Potassium chloride Ø Sodium chloride Ø Potassium di hydro ortho phosphate Sodium di hydro ortho phosphate 6. Freeze Drying: Freeze-drying (also known as lyophilisation or cry desiccation) is a dehydration process typically used to preserve a perishable material or make the material more convenient for transport. Freeze-drying works by freezing the material and then reducing the surrounding pressure and adding enough heat to allow the frozen water in the material to sublime directly from the solid phase to gas. There are several stages involved in the freeze drying process 6.1 Freezing stage: â€Å" The freezing process consists of freezing the material. In a lab, this is often done by placing the material in a freeze-drying flask and rotating the flask in a bath, called a shell freezer, which is cooled by mechanical refrigeration, dry ice and methanol, or liquid nitrogen. On a larger-scale, freezing is usually done using a freeze-drying machine. In this step, it is important to cool the material below its eutectic point, the lowest temperature at which the solid and liquid phases of the material can coexist. This ensures that sublimation rather than melting will occur in the following steps. Larger crystals are easier to freeze-dry. To produce larger crystals, the product should be frozen slowly or can be cycled up and down in temperature. This cycling process is called annealing. However, in the case of food, or objects with formerly-living cells, large ice crystals will break the cell walls (discovered byClarence Birdseye)†. Usually, the freezing temperatures ar e between -50  °C and -80  °C. The freezing phase is the most critical in the whole freeze-drying process, because the product can be spoiled if badly done. Amorphous (glassy) materials do not have an eutectic point, but do have a critical point, below which the product must be maintained to prevent melt-back or collapse during primary and secondary drying. 6.2 Primary drying: â€Å" Primary drying can reduce the moisture content of a freeze dried solid to around 0.5%. Further reduction can be effected by secondary drying. During the primary drying, the latent heat of sublimation must be provided and the vapour removed. enough heat is supplied to the material for the water to sublimate In this initial drying phase, about 95% of the water in the material is sublimated. This phase may be slow (can be several days in the industry), because, if too much heat is added, the materials structure could be altered†. 6.3 Secondary drying: The removal of residual moisture at the end o primary drying is performed by raising the temperature of the solid to as high as 50 °C or 60 °C. A high temperature is permissible for many materials because the small amount of moisture remaining is not sufficient to cause spoilage 6.4 Freeze drying advantages: Drying takes place at very low temperatures, so that enzyme action is inhibited and chemical decomposition, particularly hydrolysis, is minimised. The solution is frozen such that the final dry product is a net work of solid occupying the same volume as the original solution. Thus the product is light and porous. The porous form of the product gives ready solubility. There is no concentration of the solution prior to drying. Hence, salts do not concentrate and denature proteins, as occurs with other drying methods. As the process takes place under high vacuum there is little contact with air, and oxidation is minimized. 6.5 Freeze drying disadvantages: The porosity, ready solubility and complete dryness yield a very hygroscopic product. Unless products are dried in their final container and sealed in situ, packaging requires special conditions. The process is very slow and uses complicated plant, which is very expensive. It is not a general method of drying, therefore, but is limited to certain types of valuable products which, because of their heat sensitivity, cannot be dried by any other means. 7 Apparatus used for the experiment : 7.1 Uv_visible spectroscopy: â€Å" A diagram of the components of a typical spectrometer is shown in the following diagram. The functioning of this instrument is relatively straightforward. A beam of light from a visible and/or UV light source (colored red) is separated into its component wavelengths by a prism or diffraction grating. Each monochromatic (single wavelength) beam in turn is split into two equal intensity beams by a half-mirrored device†. One beam, the sample beam (colored magenta), passes through a small transparent container (cuvette) containing a solution of the compound being studied in a transparent solvent. The other beam, the reference (colored blue), passes through an identical cuvette containing only the solvent. The intensities of these light beams are then measured by electronic detectors and compared. The intensity of the reference beam, which should have suffered little or no light absorption, is defined as I0. The intensity ofthe sample beam is defined as I. Over a short perio d of time, the spectrometer automatically scans all the component wavelengths in the manner described. The ultraviolet (UV) region scanned is normally from 200 to 400 nm, and the visible portion is from 400 to 800 nm. [11] Components of UV_ visible spectroscopy 7.2 Instrumentation: Source of light: The best source of light that which is more stable more intense and which gives range of spectrum from 180-360nm.The different sources available are: Hydrogen discharge lamp:It is more stable robust and widely used.It gives radiation from 120-350nm.The lamp consist of hydrogen under pressure. Deuterium lamp: It is similar to hydrogen discharge lamp, but filled with deuterium in the place of hydrogen.It offers 3-5 times more intensity than other types.This is most widely used but expensive. Xenon discharge lamp: In this lamp, xenon at 10-30 atmospheric pressure is filled in and has two tungsten electrodes. The intensity is greater than hydrogen discharge lamp. Mercury arc: This contains mercury vapour and offers bands which are sharp.The spectrum is not continuous. Monochromaters: â€Å"Grating monochromaters are used, filters and prism monochromaters are not used because of low resolution.On the other hand gratings provide a band pass of 0.4 to 2nm.Hence they are more widely used incase of expensive spectrophotometers.The mirrors ,gratings are made up of quartz since glass absorbs uv radiation from 200-300nm.Mirrors are front surfaced to prevent absorption of radiation†. Sample Cells: â€Å"The design of sample cells used is similar to that used in colorimetry expect that it is made up of quartz. Quartz cells only must be used in uv spectroscopy since glass cells will absorb uv radiation.The pathlength of the cells are 10mm or 1cm†. Solvents: â€Å"solvent plays an important role in uv spectra, since compound peak could be obscured by solvent peak.Hence the solvent for a sample is selected in such a way that solvent neither absorbs in the region of measurement nor affects the absorption of the sample†. Detectors: Although any one of the detectors used in colorimetry can be used, photomultiplier tubes are mainly used, since the cost of such UV spectrophotometers are high and more accurate measurements are to be made. Single beam and double beam UV spectrophotometers are used. 7.3.Beers law (related to concentration of absorbing species): Beers law states that the intensity of beam of monochromatic light decreases exponentially with increase in the concentration of absorbing species arithmetically. Lamberts law (related to thickness/ path length of absorbing species): Lamberts law states that the rate of decrease of intensity (monochromatic light) with the thickness of the medium is directly proportional to the intensity of incident light. Beer-Lambert Law: The beer lamberts law states that absorbance of a solution is directly proportionally to the concentration of the solution. A = −log_{10}(I/I_0) = epsiloncdot ccdot L, The beer-lambert law is useful for characterizing of the compounds but does not hold as a universal relationship for the concentration and absorption of all species. Applications: It is mainly used in the detection of impurities. It is used in the structure elucidation of organic compounds. And also used in the analysis of organic compounds. Detrmination of molecular weight. Determination of dissociation constant of acids and bases. 7.4 Flow through dissolution apparatus: â€Å"The flow-through cell is a suitable method for dissolution studies of poorly soluble drugs. The dissolution can be influenced by changing parameters in the apparatus and by changing the physical properties of the drug and the medium used. In this study the dissolution of ibuprofen was examined†. Results showed that a smaller particle size gave a higher dissolution rate. With a dose of 50mg a higher percent dissolved was obtained compared to a dose of 100mg. However, a larger mass (mg) was dissolved when the dose of 100mg was used. When using a cell diameter of 12mm instead of a cell diameter of 22.6mm the dissolution rate increased. A larger dissolution rate was also obtained when the flow of the medium was increased. Finally the effect of changing medium was examined. Results showed that by including a surfactant to the medium a drastic increase of the dissolution rate was obtained. The flow-through cell has since the 90s been used as an alternative method for dissolution studies . It has some advantages over previous dissolution methods. It is easier to retain sink condition, i.e. to keep a sufficiently low concentration in the remaining solution. This makes it possible to keep a constant diving force (=concentration difference) the whole time during the release experiment. The concentration should not exceed one third of the saturated. The medium can be changed automatically during the study which is very useful in in vitro in vivo studies . Previous studies have showed the importance of deaeration of the dissolution medium, how the packing of the cell can influence the dissolution and that the results obtained with the flow-through cell are more reproducible than obtained with previous methods as dissolution baths In this study the dissolution of ibuprofen was examined in the flow-through cell. Six parameters were of interest: The packing of the cell The particle size of the drug The dose The volume flow of the medium through the cell The cell diameter The medium Desirable results were good reproducibility, i.e. small standard deviation between tests and cells, and to maintain sink condition during the experiment. Advantages : Laminar flow characteristics over a wide range of solvent flow rates Infinite sink ideal for low solubility drugs Differential rather than cumulative time profile o

Value of an Education Essay -- Education School College

Value of an Education In today's society education is really important. Education has evolved a lot over time and has shaped American society. Back in the day, education was not as important because many jobs did not have educational requirements. In those days you could have a high school diploma and get a good job. Today, if you only have a high school diploma the types of jobs that you can get include fast food restaurants or maybe construction work. Getting your college degree is very essential to your economic success and your ability to get a good job that pays well. Prior to entering college in the fall, I felt that college would be very challenging for me because of what my friends that were already attending college told me. I feel that high school as a whole does not prepare you for work at the college level. Many people in high school study very little or they might not study at all and they can still maintain an A average. At the college level you can not study very little and expect to get the same results. If high school better prepared students for college there would be more college students making it to their sophomore years of college instead of dropping out. Another big difference between high school and college is the fact that there is so much freedom in college. In high school you are on such a tight leash that you are forced to do things that you aren't forced to do in college. For example, in high school, if you don't go to class, your parents will be notified. In college, you're on your own and you need to make the decision t o go class as scheduled. I think that this is one of the main reasons why students flunk out of college. Many students at the age of 18 and 19 see that most classes don't take ... ...education very highly, so it is fitting that the University of Kentucky do the same. Values teach us that we can reach as high as we can, rather than cutting ourselves short. The University offers highest standards of achievement which enable students to realize their full potential. I believe that the University of Kentucky is a good school that supports every student to be the best they can be. " A school that operates with a set of values that ensures a common and consistent code of respectful and responsible behavior makes a significant difference. Students learn far better when they are a part of a school that consciously applies values education policies, behavior strategies and teaching programs that employs trained teachers who can discuss values issues in all areas of the curriculum." Lawley, Judy. Living Values. Values Education, 2003

Girls Development During Adolescence: Diminishment of Self Essay

Large numbers of American girls face a crisis during adolescence. Numerous studies document the disturbing trends that affect girls during this vulnerable time. Girls' IQ scores drop. Their grades in math and science decline dramatically. The confidence, curiosity, and willingness to take risks that mark their childhood years are replaced by unassertiveness, boredom, and a cleaving to the status quo. Girls at this age become prone to eating disorders, self-mutilation, and depression. Even girls without obvious signs of distress undergo a curious diminishing, as if all the interests and energies of their childhood must now be channelled into maintaining a narrow and alien definition of self. What happens to girls as they grow up? What causes this diminishment of self? What transforms them from the happy, confident people they are in childhood to the self-critical, sullen, and frightened adolescents they become? Psychologist Mary Pipher, author of Reviving Ophelia: Saving the Selves of Adolescent Girls talks about the "isms" that meet girls at the threshhold of adolescence--sexism, capitalism, and lookism. Who girls can be is no longer a wide-open playing field. They find themselves judged by how well they conform to a specific gender role. An enormous source of information about what it means to be female is the popular media. Music and music videos, movies, television, magazines, and commercials, many of them aimed at teenagers, all carry a loaded message--to be successful as a woman means adhering to a highly stylized script that defines for girls what womanhood is. Modern girls encounter an incredible contradiction in the messages they receive at this vulnerable time in their lives. On the one hand they ar... ...lem. We are buying into the mentality that fuels those images. Each of us must have the courage to examine our own unconscious pact with the scripts society hands us. We need to recognize the ways our power has been co-opted by the rewards we reap through compliance with the status quo. In what ways does our own diminishment hold us back? Can we move beyond that diminishment and reclaim our right to be whole? Can we step outside the gender boundaries we have internalized into a place where we finally exist as humans, first, and men and women second? It is through claiming our own integrity that we give girls permission to expand beyond the status quo. It is our choice. When enough of us have moved beyond the cultural icons that define for us what masculinity and femininity are, those icons will fall away. There won't be an audience left to sustain them.

Theories Actually Seen in Practice in Ojt

Assessment of the OJT/Practicum Program A. New knowledge, attitudes, and skills acquired I learned the flows and transaction in the Government process. Though, most of the work involves papers in procedural ways. The receiving and releasing of memorandum is very essential in a way that affects the flow of the work and it should be submitted on or before deadline, so as the require data. As I was expose to this environment, it not much different with the projects at schools, terms papers that have deadline and of course you must know what you have on those papers because you might be question for it. B. Theories actually seen in practice In Technical Education and Skills Development Authority (TESDA), the community and client service exists in theory, but in practice there are few officials who work in it. They have philanthropy theory and giving good intensions for the good but some of it lacks of practice because of its manpower. Though, they have a good goal towards it. C. Feedback that can be given to the company or institution The mission and vision of the company is great, it really reflect the needs of the Filipino citizen especially to the youth. It offers vocational courses that can help the youth to find work or build up their own business. In that way, it will lessen the population of unemployed individuals. But as I observe, the processing of its transaction and others are sometimes delayed due to many unfinished transaction. The workers are minimal, and the works are exceeding its normal worker. It leads to unbalanced ratio of work, they lack of manpower. If only they have much worker or officials that only work to specific job at a time, they can render its service with utmost confidentiality and transactions will be process on time. And also with their worker, some of the workers don’t do immediately their work, they will just wait until the deadline is near. And when it is almost the deadline, that’s the time they will tend to the work, sometimes lead to many erasure and errors of data they put on their reports. The result, some of the transaction will be delayed because the worker will be invalid at the moment. D. Benefits gained The things or knowledge that I gained from working in Technical Education and Skills Development Authority (TESDA) is that the government work is not that easy. It has many structure and procedures that must be followed before it is done or implemented. It will go under observation and studies before it is approved from the head of the agency. That’s why, it will takes months or even years before it is practice, some of us citizen’s complain why it’s not implemented directly, or done immediately. The cash flows, the money that are allotted to its specific project. It must liquidate thoroughly, because they will question it, even a single cent that is missing to data. They are very careful with it, especially when the heads of the agency will conduct unnoticed visit to conduct inspection for the cash flows report they have. E. Problems encountered They are various problems that I encounter within the first month I work in, but most of them are repeated actions; error in logging the receiving letters and releasing, error in checking the database in the enrollment and terminal report against the database, error in answering the telephone and mistakes in putting some data in the records room. But I overcome these problems, because it’s just the same old routine every day, so I easily adjust and remember my errors.